Sunday, December 5, 2021
Home Health Researchers identify blood-based biomarkers for brain tumours - ET HealthWorld

Researchers identify blood-based biomarkers for brain tumours – ET HealthWorld


Bengaluru: Indian Institute of Science (IISc) researchers, along with their collaborators, have identified potential blood-based biomarkers to predict disease progression and survival times in those with late-stage brain tumours. Researchers, however, caution that further testing and validation on a larger scale is necessary before this can be taken from the lab to the clinic.

The team — comprising researchers from IISc’s Centre for BioSystems Science and Engineering, the Mazumdar Shaw Centre for Translational Research and the Mazumdar Shaw Medical Foundation — analysed tumour and blood samples from individuals with gliomas (tumours that occur in the brain) to identify surface proteins on immune cells in the blood whose levels were closely linked to tumour progression.

In the study that has been published in OncoImmunology, researchers pointed out that late-stage gliomas such as grade three and grade four gliomas are associated with a poor prognosis — the tumour is harder to treat and the patient is likely to have a low chance of survival.

“Our pilot study suggests that we can potentially use two blood-based biomarkers present on immune cells to identify patients who might not perform well with particular treatment strategies,” Siddharth Jhunjhunwala, assistant professor, BSSE, and senior author of the study says.

Such a blood-based testing methodology, researchers said, could help clinicians better understand disease progression and choose a more effective treatment regimen.

Pointing out that conventional cancer treatments like chemotherapy are often ineffective in treating these tumours, they said it has prompted a shift to newer techniques like immunotherapy, which involves provoking our own immune system to attack the tumour cells.

However, attempts to use some of the standard immunotherapies to treat gliomas have met with limited success, Jhunjhunwala explains, adding: “This led to a specific scientific gap that we were trying to address, which is to understand the immune profile in the tumour microenvironment.”

The team collected blood and tumour samples from patients with grade three and grade four gliomas, and compared the numbers of specific immune cells called monocytes and neutrophils in these samples.

“Because these are biosamples, they need to be preserved and processed very well without loss of cell viability. We had to split up methodology between two institutes — here and at the lab at the Mazumdar Shaw Foundation. They would do all the processing and fixation to retain the viability of the cells, and then we would do the characterisation and immunostaining here,” explains Jayashree V Raghavan, PhD student at BSSE and first author of the study.





Source link

RELATED ARTICLES

Double vaccinate against Covid first, experts say amid calls for booster shots – ET HealthWorld

NEW DELHI: India should prioritise double vaccinating its eligible population against Covid over booster shots given the large number of people still to...

BioNTech CEO confident of quickly adapting vaccine for Omicron – ET HealthWorld

FRANKFURT: Germany's BioNTech should be able to adapt its coronavirus vaccine relatively quickly in response to the Omicron variant, its CEO Ugur Sahin...

18 of 16000 flyers from at-risk nations test positive; genome sequencing for Omicron underway: Govt – ET HealthWorld

NEW DELHI: Health minister Mansukh Mandaviya on Friday informed Parliament that RT-PCR tests of 16,000 passengers from 'at-risk' countries have been conducted so...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

- Advertisment -stock market course

Most Popular

Cryptocurrency Bill: Stakeholders pitch for regulation

https://tech.hindustantimes.com/tech/news/cryptocurrency-bill-stakeholders-pitch-for-regulation-71638645477775.html Cryptocurrency Bill: Stakeholders ... https://tech.hindustantimes.com/tech/news/bill-gates-jeff-bezos-elon-musk-and-paul-mccartney-71638644566829.html Bill Gates, Jeff Bezos, Elon Musk ... https://tech.hindustantimes.com/tech/news/burj-khalifa-sized-asteroid-heading-towards-earth-says-nasa-71638626960758.html Burj Khalifa sized asteroid ... https://tech.hindustantimes.com/tech/news/bitcoin-price-today-fell-by-a-fifth-even-as-1-bn-wealth-in-cryptocurrencies-destroyed-71638625481027.html Bitcoin price today fell by a ... /* window.addEventListener('load', (event) =>...

51% difference in road death numbers from 2 departments | India News – Times of India

NEW DELHI: In a curious case of how two government agencies can come up with two sets of data on the same issue,...

Amid Omicron fears, Rio cancels huge New Year’s celebration – Times of India

RIO DE JANERIO: Rio de Janeiro has decided "with sadness" to cancel its huge New Year's celebration amid rising concerns over the spread...

The Variant Hunters: Inside South Africa’s Effort to Stanch Dangerous Mutations

NTUZUMA, South Africa — A few months ago, Sizakele Mathe, a community health worker in this sprawling hillside township on the edge of...

Recent Comments

%d bloggers like this: